Which treatment is the first line for Primary, Secondary, and Early Latent Syphilis?

The first-line treatment for Primary, Secondary, and Early Latent Syphilis is Penicillin G Benzathine. This form of penicillin is preferred because it is highly effective in curing syphilis and has a long half-life, allowing for sustained drug levels in the body following a single intramuscular injection.

When used to treat syphilis, Penicillin G Benzathine targets the Treponema pallidum bacteria responsible for the infection. Its proven efficacy in clinical studies makes it the standard treatment recommended by guidelines from organizations such as the Centers for Disease Control and Prevention (CDC). For the various stages of syphilis — Primary and Secondary, which are typically characterized by systemic and local lesions, and Early Latent stage with no symptoms yet possibly infectious — this treatment adequately addresses the infection and prevents further complications.

Other options listed are not appropriate first-line treatments for this condition. For example, metronidazole is not an effective agent against Treponema pallidum and is usually reserved for other infections like bacterial vaginosis or certain protozoal infections. Aqueous Crystalline Penicillin G, while effective, is generally used for severe infections and is not necessary for uncomplicated syphilis. Ceftriaxone