What is the recommended first line treatment for Trichomonas vaginalis?

Metronidazole is the recommended first-line treatment for Trichomonas vaginalis, a common sexually transmitted infection caused by a protozoan parasite. This medication effectively targets the anaerobic metabolism of the parasite, leading to its eradication. Metronidazole can be administered orally or vaginally, with the oral route being the most commonly prescribed.

This choice is supported by clinical guidelines, which recommend a single dose of 2 grams for adults or a 7-day course of 500 mg twice daily. Metronidazole has a well-established safety profile and efficacy in treating this infection. The success of this treatment is attributed to Metronidazole’s ability to disrupt DNA synthesis in the organism, thereby eliminating the infection.

In contrast, the other medications listed are not appropriate for treating Trichomonas vaginalis. Azithromycin, although effective against other bacterial infections, does not target the protozoan. Doxycycline primarily treats bacterial infections and is not indicated for Trichomonas. Ceftriaxone is used for certain bacterial infections, particularly those caused by Neisseria gonorrhoeae, but is not effective against this protozoan parasite. Thus, Metronidazole is the established and effective first-line treatment