What is the first line treatment for Disseminated Gonococcal Infection?

The first-line treatment for Disseminated Gonococcal Infection (DGI) is Ceftriaxone. This is because Ceftriaxone is a broad-spectrum cephalosporin antibiotic that is effective against Neisseria gonorrhoeae, the bacterium responsible for gonorrhea and related infections. DGI can present with systemic symptoms and requires effective parenteral therapy, which Ceftriaxone can provide due to its potency and ability to penetrate tissues.

Ceftriaxone is administered intravenously or intramuscularly, which is particularly important in serious infections where quick and effective treatment is crucial. Clinical guidelines recommend this agent because of its excellent effectiveness and safety profile in treating both uncomplicated and complicated gonococcal infections.

While other antibiotics like Azithromycin and Doxycycline are also used for various infections, they are not the first choice for DGI. Azithromycin may be used in combination therapies but is not the sole treatment for a disseminated infection. Doxycycline is primarily used for other types of infections and does not target Neisseria gonorrhoeae effectively enough for serious cases like DGI. Penicillin G Benzathine, while useful for syphilis and certain other bacterial infections,